Ngubane, ZesizweDzwairo, BloodlessSokolova, EkaterinaMoodley, BrendaStenstrom, Thor Axel2023-10-302023-10-302023-10-24Ngubane, Z., et al. 2023. Quantitative assessment of human health risks from chemical pollution in the uMsunduzi River, South Africa. Environmental Science and Pollution Research. doi:10.1007/s11356-023-30534-40944-1344https://hdl.handle.net/10321/5026A quantitative chemical risk assessment was performed using published data as well as data from the official monitoring programme for the uMsunduzi River in KwaZulu-Natal, South Africa. The chemicals assessed were organochlorinated pes- ticides (OCPs), pharmaceuticals and personal care products (PPCPs), heavy metals, and nitrates and phosphates. The water from uMsunduzi River is used locally without treatment. Consequently, the exposure routes investigated were via ingestion during domestic drinking and incidental ingestion during recreational activities, which were swimming and non-competitive canoeing, for both adults and children. For the individual chemicals, non-carcinogenic risks using the hazard quotient (HQ) and carcinogenic risks using the cancer risk (CR) were quantified. It was found that the exposed population is likely to experience non-carcinogenic effects from pesticides and phosphates, but not from PPCPs, heavy metals and nitrates. This study also found that the carcinogenic risks for OCPs were higher than the tolerable limit of 10-5, while for lead the risk was below the tolerable limit. Some of the activities that potentially contribute to chemicals onto the uMsunduzi River are sub- sistence farming, small plantations, illegal dumping, industries, and broken sewers. The findings of this study may act as the technical foundation for the introduction of pollution reduction measures within the catchment, including public education12 pen03 Chemical Sciences05 Environmental Sciences06 Biological SciencesEnvironmental SciencesHeavy metalsNitratesOrganochlorinated pesticidesPharmaceuticals and personal care productsPhosphatesQuantitative chemical risk assessmentArticle2023-10-2710.1007/s11356-023-30534-4