Sabela, Myalowenkosi InnocentSingh, ParveshGumede, Njabulo JoyfullBisetty, KrishnaSagrado, Sagrado2014-05-152014-05-152012Sabela, M.I., Singh, P., Gumede, N.J., Bisetty, K. and Sagrado, S. 2012. Evaluation of Enantioresolution of (±)-Catechin using Electrokinetic Chromatography and Molecular Docking." Journal of Scientific Research in Pharmacy. 1(2): 1-4.2277-9469http://hdl.handle.net/10321/983This study involves the enantioresolution of (±) catechin with the highly sulphated beta cyclodextrin (HS-β-CD) as a chiral selector using capillary electrophoresis (CE). The purpose of this study was to be tter understand enantioresolution amongst host-guest interactions. Furthermore, molecular docking was carried out to elucidate the mechanism of the enantioselective separations of (±) catechin enantiomers obtained in Electrokinetic chroma tography (EKC). A large difference in the interaction energies observed between the two enantiomers represents significant enantiodifferentiation. Our results also suggest that the host-guest interactions between the phenyl ring of the ligand and the open cavity of the HS-β-CD are due mainly to hydrophobic interactions. Interestingly, the stronger interactions observed with (+)-catechin is consistent with the elution order observed in the CE experiments.4 penEnantioresolutionElectrokinetic chromatography (EKC)Molecular dockingCatechinArticle