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Research Publications (Applied Sciences)

Permanent URI for this collectionhttp://ir-dev.dut.ac.za/handle/10321/213

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Author: search.filters.author.Krishna, Suresh Babu NaiduSubject: search.filters.subject.Antioxidant

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    Green synthesis of silver nanoparticles from Hibiscus tiliaceus L. Leaves and their applications in dye degradation, antioxidant, antimicrobial, and anticancer activities
    (Elsevier BV, 2024-05) Konduri, Vinay Viswanath; Kalagatur, Naveen Kumar; Gunti, Lokanadhan; Mangamuri, Usha Kiranmayi; Kalagadda, Venkateswara Rao; Poda, Sudhakar; Krishna, Suresh Babu Naidu
    The present study reports the green synthesis of silver nanoparticles (AgNPs) from aqueous extract of Hibis cus tiliaceus L. leaves and their application in dye degradation, antioxidant, antimicrobial, and anticancer activities. Analysis using Fourier transform infrared (FT-IR) spectroscopy revealed that plant metabolite func tional groups had a role in the reduction and stability of AgNPs, and X-ray crystallography (XRD) demon strated that the AgNPs were in crystal form. The UV vis spectroscopy, dynamic light scattering (DLS), and zeta potential investigations revealed that the AgNPs were formed with an average size of 88.10 nm in colloi dal form and were stable (-49 mV). The field emission scanning electron microscopy (FE-SEM) and high-reso lution transmission electron microscopy (HR-TEM) confirmed the shape and size of the AgNPs as spherical with a particle size of 30 - 35 nm, respectively. The AgNPs exhibited potential antioxidant activity by total antioxidant, DPPH, and reducing power assays. The biosynthesized AgNPs displayed a wide range of antibac terial activity on Gram-ve and Gram+ve bacteria by the zone of inhibition assay. AgNPs showed good antican cer activity on MCF-7 cells with an IC50 value of 65.83 mg/mL. Furthermore, AgNPs acted as potential catalysts in combination with the reducing agent sodium borohydride (NaBH4) for the degradation of methylene blue (MB), methylene orange (MO), and methylene green (MG) dyes. The degradation efficiency of catalyst AgNPs in the attendance of NaBH4 for 15 min was noted to be 12.8 %, 26.92 %, and 47.56 % for MO, MB, and MG, respectively. The study concluded that green synthesized AgNPs could be highly applicable as an antioxidant, antimicrobial, and anticancer agents in the biomedical field. Furthermore, AgNPs could be helpful in the remediation of dye effluents.
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    Antioxidant potential of zephyranthes citrina seed extract in saccharomyces cerevisiae’s oxidative stress response system
    (Association of Biotechnology and Pharmacy, 2023-10-15) Patil, Sharangouda J.; Jyothi, Renuka; Sadashiv, S. O.; Vishwantaha, T.; Adam, Jamila Khatoon; Krishna, Suresh Babu Naidu
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    Emergent roles of garlic-based nanoparticles for bio-medical applications : a review
    (Association of Biotechnology and Pharmacy, 2021-08-18) Krishna, Suresh Babu Naidu; KRSS, Sambasiva Rao
    Garlic (Allium sativum L.) is well renowned for its antimicrobial potential and broadly consumed spice globally for its medicinal properties. Moreover, several studies advocate that garlic contains many bioactives that demonstrate strong therapeutic properties in treating cardiovascular diseases, digestive system, diabetes, cancer, obesity, hypertension, inflammation, antioxidant, and viral infection. Presently, therapeutics of natural origin are drawing major interest among consumers due to their antimicrobial efficacy and safety. Garlic extracts, chitosan by- products, several spices and antimicrobial peptides are illustrations for such products. The present review paper inspects briefly the major active ingredients and key biological functions of garlic based nanoparticles discussing the relevant mechanisms of actions.