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Research Publications (Applied Sciences)

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    Sulfonic acid functionalized boron nitride nano materials as a microwave-assisted efficient and highly biologically active one-pot synthesis of piperazinyl-quinolinyl fused Benzo[c]acridine derivatives
    (Elsevier, 2017) Murugesan, Arul; Gengan, Robert Moonsamy; Anand, Krishnan
    Boron nitride nano material based solid acid catalyst was found to be an efficient and reusable sulfonic acid catalyst for the synthesis of one-pot Knoevenagel and Michael type reactions in 3, 3-dimethyl-9-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-3, 4, 9, 10-tetrahydroacridin-1(2H)-one derivatives under mi-crowave irradiation conditions. The catalyst was prepared by mixing boron nitrile and (3-mercaptopropyl) trimethoxysilane. This is simple and safe method for the preparation of solid acid catalysts. The morphological properties of catalyst determined by using FT-IR, XRD, TEM, SEM and Raman spectroscopy. The synthesised catalyst was employed in Knoevenagel and Michael type reactions to synthesise novel piperazinyl-quinolinyl based acridine derivatives. Furthermore the newly-synthesised compounds have been used for molecular docking in DNA binding studies. The method developed in this study has the advantages of good yield, simplicity coupled with safety and short reaction time. Most importantly it was found that the solid acid catalyst can be recycled with only 5% loss of activity.
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    Synthesis and antimosquito properties of 2,6-substituted benzo[ d ] thiazole and 2,4-substituted benzo[ d ]thiazole analogues against Anopheles arabiensis
    (Elsevier, 2013-07) Venugopala, Katharigatta Narayanaswamy; Krishnappa, Krishnappa; Nayak, Susanta K.; Subrahmanya, Bhat K.; Vaderapura, Jayashankaragowda P.; Chalannavar, Raju K.; Gleiser, Raquel M.; Odhav, Bharti
    A novel and efficient one pot synthesis was developed for 2,6-substituted-benzo[d]thiazole analogues 4a–k and 2,4-substituted-benzo[d]thiazole analogues 4l–pvia three component condensation reaction of substituted arylaldehyde, 2-amino-6-halo/4-methyl-benzo[d]thiazole and 2-naphthol or 6-hydroxyquinoline in presence of 10% w/v NaCl in water by microwave method. This method enabled for short reaction times, easy work-up and significant high yields. The title compound 4b was used for single crystal X-ray studies in order to understand its conformation and packing features. The title compounds 4a–p were screened for antimosquito properties such as repellency, insecticidal and larvicidal activity against Anopheles arabiensis by mosquito feeding-probing assay, cone bio-assay and standard WHO larvicidal assay, respectively. Among these analogous 4b, 4d and 4p exhibit the highest repellent activity comparable to the positive control DEET, and 4a and 4k knockdown most mosquitoes on repellent assays.