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    Biosynthesis of bimetallic Au-Ag nanoparticles using Ocimum basilicum (L.) with antidiabetic and antimicrobial properties
    (VBRI Press, 2015) Malapermal, Veshara; Mbatha, Joyce Nonhlanhla; Gengan, Robert Moonsamy; Anand, Krishnan
    This study was aimed at developing a simple, eco-friendly and cost effective green chemistry method for the synthesis of bimetallic Au-Ag nanoparticles using Ocimum basilicum aqueous leaf and flower extracts, respectively as the natural reducing agents. The successive reduction of chloroauric acid and silver nitrate led to the formation of Au-Ag nanoparticles within 10 min at room temperature, suggesting a higher reaction rate than chemical methods involved in the synthesis. Stable, spherical nanoparticles with well-defined dimensions of average size of 3-25 nm was confirmed by UV-Visible spectroscopy, TEM, SEM-EDX, DLS, and zeta potential, whilst, FTIR in combination with GC-MS analyzed the functional groups adhered to the surface of the nanoparticles. The colloidal suspension displayed enhanced antihyperglycemic activity at 69.97 ± 3.42% (leaf) against α-amylase (from porcine) and at 85.77 ± 5.82% (flower) against Bacillus stearothermophilus α-glucosidase than that of acarbose and their respective crude extracts. Furthermore, revealed good antibacterial activity against bacterial species Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa. Copyright © 2015 VBRI Press.
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    The value of chiropractic manipulative treatment in the management of insulin-dependent diabetes mellitus
    (1995) Long, Warren Stephen; Walters, M. M.
    Subjects who were previously diagnosed as having insulin dependent diabetes mellitus (i.d.d.m.) were treated in a single blind, randomised, placebo controlled trial. The objective of this study was to evaluate the efficacy of chiropractic treatment in the management of i.d.d.m. The sample of 21 subjects was randomly divided into an experimental group of Il subjects and a control group of 10 subjects. At the initial consultation, a case history and physical examination was performed on each subject and an informed consent form, screening questionnaire and subjective health status questionnaire (S.H.S.Q.) were completed by each subject. Each subject was required to be in possession of a glucometer. The subjects were treated once a week for a period of four months. Glycosylated haemoglobin readings were taken before the commencement of treatment, after two months and at the' end of the study. Venous glucose readings were taken before treatment was started and for every two weeks thereafter. (i i) Subjects in the experimental group received chiropractic manipulation of anysubluxations detected within the vertebral levels of CO - e3 and T7 - Tl2. Subjects in the control group received vacotron suction pads from an interferential unit over the transpyloric plane with the milliamperage set at zero.