Faculty of Applied Sciences

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Green synthesis of metal nanoparticles for antimicrobial activity
(IntechOpen, 2021-06-09) Moodley, Jerushka S.; Krishna, Suresh Babu Naidu; Pillay, Karen; Govender, Patrick; Karthikeyan, Krishnamoorthy
The development and extensive spread of multi-drug resistant bacteria are considered as a major public health concern. Failures to control severe infections due to antibiotic resistance have augmented healthcare costs as well as patient morbidity and mortality. Presently, natural product-based therapeutics are gaining significant attention both for their antimicrobial effectiveness and for not persuading drug resistance. Furthermore, recent developments in nanoscience on new drug delivery systems built on nanostructured materials from plants and microbes have emerged which focus on targeted delivery and controlled release of therapeutic agents. This review examines the recent investigations on the biological activities of plant and bacterial biological material for silver nanoparticle (AgNP) synthesis. Also, the underlying mechanism of antimicrobial activities of silver nanoparticles against human pathogens will be discussed. A fact of the biological activities and/or chemical responses of plants is required, not only for the discovery of new therapeutic agents, but because such evidence may be of value in disclosing new sources of already known biologically active compounds.