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Urea/oxalamide tethered b-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluation

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dc.contributor.authorSingh, Pardeepen_US
dc.contributor.authorRaj, Raghuen_US
dc.contributor.authorSingh, Parveshen_US
dc.contributor.authorGut, Jirien_US
dc.contributor.authorRosenthal, Philip J.en_US
dc.contributor.authorKumar, Vipanen_US
dc.date.accessioned2015-09-28T08:15:34Z
dc.date.available2015-09-28T08:15:34Z
dc.date.issued2013-11-09
dc.description.abstractThe manuscript pertains to the synthesis of urea/oxalamide tethered b-lactam-7-chloroquinoline con-jugates with well modulated chain lengths and their antimalarial evaluation. The results reveal the dependence of activity profiles on the N-1 substituent of the b-lactam ring, the nature of the linker as well as the length of the alkyl chain. The most potent of the tested compounds showed an IC50 of 34.97 nM against chloroquine resistant W2 strain of Plasmodium falciparum.en_US
dc.dut-rims.pubnumDUT-003785en_US
dc.format.extent7 pen_US
dc.identifier.citationSingh, P.; Raj, R.; Singh, P.; Gut, J.; Rosenthal, P. J. and Kumar, V. 2014. Urea/oxalamide tethered b-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluation. European Journal of Medicinal Chemistry. 71 (2014) 128-134.en_US
dc.identifier.doihttps://doi.org/10.1016/j.ejmech.2013.10.079
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/10321/1353
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean journal of medicinal chemistryen_US
dc.subjectb-Lactam-7-chloroquinoline conjugatesen_US
dc.subjectUrea/oxalamide linkeren_US
dc.subjectAntimalarial evaluationen_US
dc.subjectStructureeactivity relationshipen_US
dc.titleUrea/oxalamide tethered b-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluationen_US
dc.typeArticleen_US
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