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Antibodies to erythropoietin are associated with erythropoietin resistance in hemodialysis patients in KwaZulu-Natal (South Africa)

dc.contributor.authorBenjamin, Sherileneen_US
dc.contributor.authorAdam, Jamilaen_US
dc.contributor.authorKrishna, Suresh Babu Naiduen_US
dc.contributor.authorAssounga, Alain G.en_US
dc.date.accessioned2024-04-24T10:02:26Z
dc.date.available2024-04-24T10:02:26Z
dc.date.issued2020
dc.date.updated2024-04-19T13:34:42Z
dc.description.abstractRecombinant human erythropoietin (rHuEPO) is a glycoprotein and biological equivalent to the endogenous compound administered to treat anemia of end-stage renal disease patients. Resistance to rHuEPO has been reported, whereby patients require higher and higher doses of rHuEPO to maintain an adequate hemoglobin level. In this study, assessment of native and administered erythropoietin (EPO), antibody and hemoglobin levels was carried out on a sample of patients with renal failure on hemodialysis (HD). This is a randomized controlled trial where consecutive subjects attending HD units at Addington Hospital and King Edward Hospital, Durban (South Africa) were included until the target number was reached. Forty patients with renal failure on HD and receiving recombinant EPO Beta (Recormon) for treatment of anemia via the subcutaneous route in weekly doses of 2000 IU, 4000 IU, 6000 IU, 8000 IU, 12,000 IU, or 18,000 IU according to the severity of the anemia were included after obtaining informed consent. Also included in the study were 10 HD patients not on rHuEPO therapy and 10 healthy individuals from the Durban University of Technology, recruited as described above to form the control group. ELISA was used to measure serum levels of EPO as well as antibodies to EPO. Results were analyzed by descriptive, inferential methods and by logistic regression analysis using IBM SPSS Statistics for Windows version 22.0. Antibodies to EPO were found in almost all patients who were receiving EPO. The highest levels of antibody to EPO were found to be associated with patients receiving the highest weekly dose of EPO (18,000 IU). Logistic regression analysis also revealed that serum levels of EPO, gender or age were not associated with any significant variation of serum antibody level. High levels of serum antibodies to EPO are a risk factor for EPO resistance.en_US
dc.format.extent10 pen_US
dc.format.mediumPrint
dc.identifier.citationBenjamin, S., Adam, J., Krishna, S.B.N. and Assounga, A.G. 2020. Antibodies to erythropoietin are associated with erythropoietin resistance in hemodialysis patients in KwaZulu-Natal (South Africa). Saudi Journal of Kidney Diseases and Transplantation. 31(5): 917-926. doi:10.4103/1319-2442.301198en_US
dc.identifier.doi10.4103/1319-2442.301198
dc.identifier.issn1319-2442
dc.identifier.issn2320-3838 (Online)
dc.identifier.otherisidoc: PB7GW
dc.identifier.otherpubmed: 33229756
dc.identifier.urihttps://hdl.handle.net/10321/5275
dc.language.isoenen_US
dc.publisherMedknowen_US
dc.publisher.urihttps://www.sjkdt.org/text.asp?2020/31/5/917/301198en_US
dc.relation.ispartofSaudi Journal of Kidney Diseases and Transplantation; Vol. 31, Issue 5en_US
dc.subjectAntibodiesen_US
dc.subjectErythropoietinen_US
dc.subjectErythropoietin resistanceen_US
dc.subjectHemodialysisen_US
dc.subjectPatientsen_US
dc.subject.meshHumans
dc.subject.meshKidney Failure, Chronic
dc.subject.meshErythropoietin
dc.subject.meshRecombinant Proteins
dc.subject.meshAntibodies
dc.subject.meshRenal Dialysis
dc.subject.meshProspective Studies
dc.subject.meshDrug Resistance
dc.subject.meshMiddle Aged
dc.subject.meshSouth Africa
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshAntibodies
dc.subject.meshDrug Resistance
dc.subject.meshErythropoietin
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshKidney Failure, Chronic
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProspective Studies
dc.subject.meshRecombinant Proteins
dc.subject.meshRenal Dialysis
dc.subject.meshSouth Africa
dc.titleAntibodies to erythropoietin are associated with erythropoietin resistance in hemodialysis patients in KwaZulu-Natal (South Africa)en_US
dc.typeArticleen_US

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