Purposes: In today's business landscape, success isn't solely reliant on financial goals. Adapting to the global economy is crucial for a company's viability. Stakeholders prioritize business sustainability, evident in empirical studies exploring sustainable supply chain management theories in the sector. The study aimed to assess how Sustainable Supply Chain in Ghana's Pharmaceutical Sector influences firm performance within the upstream industry.

Method: The study was conducted in the accessible southern part of Ghana, known for its concentration of pharmaceutical companies. Specifically, individuals involved in procurement and supply chain activities within these companies were selected for inclusion in the study. The study used quantitative methods to explore Sustainable Supply Chain Management (SSCM) in the upstream pharmaceutical industry. Out of 2000, 210 managers were randomly sampled, and SPSS Version 26 was employed for structural equation modeling (SEM) analysis.

Results and Conclusion: The study found that there was a significant relationship between SSCM and supply chain performance (SSCMP). Besides, the study found moderation impact between Top Management Commitment (TMC) and SSCM and SSCMP respectively. Pharmaceutical companies should not solely focus on economic performance; rather, strategic efforts and policies must prioritize sustainability. Top management commitment is crucial for enhancing supply chain performance. Their dedication ensures the integration of Sustainable Supply Chain Management (SSCM) with strategic objectives, embedding sustainability across the entire supply chain, from procurement to distribution.

Research Implication: Top management should drive sustainability strategy, integrating it into operations and fostering a culture of sustainability for robust Sustainable Supply Chain Management in the pharmaceutical upstream sector.Originality/Value: the study leverages on the theoretical understanding of upper echelon theory to provide empirical evidence on the impact of top management commitments on performance of supply chain which hitherto has been scarcely deployed in recent years

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