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Author: search.filters.author.Murugesan, Arul

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    Synthesis of nitrogen heterocycles and chalcones using multi-component reactions : a spectral and protein binding investigation
    (2018) Murugesan, Arul; Gengan, Robert Moonsamy
    Chemicals were purchased from Merck, Sigma Aldrich. The reaction/purity of the product was monitored and accomplished by TLC. FT-IR spectra were recorded in the range of 4000-400 cm-1 on a JASCO FT/IR-460 spectrophotometer using KBr pellets. A Bruker D2 PHASER powder diffraction instrument; Cu Kα ray (wavelength λ = 0.154056 nm), was used to measure in a continuous step-scan mode: the minimum width of the stage 0.031°, equilibrium time of 256 seconds, the operating voltage to 30 kV with 10 mA. Scanning electron microscopy (Joel JSM 7600 F) was employed to characterize the morphology. High Resolution-Transmission Electron Spectroscopy was used. The BET gas sorption isotherms were measured 77 K for N2, H2, and 273 and 298 K for CO2 using Micromeritics Auto pore 9500 system. Before recording gas sorption measurements, the sample was initially dehydrated at 423 K for 24 h under vacuum. Raman Spectroscopy was measured using the detector CCD (Triaxle) and the laser (He-Ne laser 632.8 nm). A TOF-MS analyser for accurate mass measurement was used. The melting point (mp) was recorded on a Buchi B-545 apparatus using open capillary tubes. NMR spectra were recorded in CDCl3 / DMSO-d6 on a Bruker Advance 400 MHz and 600 MHz instrument using tetramethylsilane as internal standard. In general for all compounds CDCl3 is used as a solvent, where DMSO-d6 has been used, it is mentioned in the experimental part. The chemical shifts were expressed in ppm. The following abbreviations are used in the NMR spectral data. s - Singlet d - Doublet t - Triplet q - Quartet m - Multiplet dd - doublet of doublet brs - broad singlet J - Coupling constant
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    Sulfonic acid functionalized boron nitride nano materials as a microwave-assisted efficient and highly biologically active one-pot synthesis of piperazinyl-quinolinyl fused Benzo[c]acridine derivatives
    (Elsevier, 2017) Murugesan, Arul; Gengan, Robert Moonsamy; Anand, Krishnan
    Boron nitride nano material based solid acid catalyst was found to be an efficient and reusable sulfonic acid catalyst for the synthesis of one-pot Knoevenagel and Michael type reactions in 3, 3-dimethyl-9-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-3, 4, 9, 10-tetrahydroacridin-1(2H)-one derivatives under mi-crowave irradiation conditions. The catalyst was prepared by mixing boron nitrile and (3-mercaptopropyl) trimethoxysilane. This is simple and safe method for the preparation of solid acid catalysts. The morphological properties of catalyst determined by using FT-IR, XRD, TEM, SEM and Raman spectroscopy. The synthesised catalyst was employed in Knoevenagel and Michael type reactions to synthesise novel piperazinyl-quinolinyl based acridine derivatives. Furthermore the newly-synthesised compounds have been used for molecular docking in DNA binding studies. The method developed in this study has the advantages of good yield, simplicity coupled with safety and short reaction time. Most importantly it was found that the solid acid catalyst can be recycled with only 5% loss of activity.